I passed by Manganaro Grosseria Italiana just last week, and almost went in for a sandwich. But didn't.
And now it's gone forever.
It's been on the books for a year now that it was on its way out. But it lingered. Not anymore. According to JVNY, the tables have been removed, the shelves emptied, and a note on the website reads, "As of February 27, 2012, Manganaro Foods will no longer be open in New York City. We will let you know when we re-open." (Looks like J. made the same mistake of not visiting when he got a chance.)
Thus ends a 121-year run.
Here's an account of a visit I paid last year about this time.